ABSTRACT
Objective@#To observe the effect of Jiawei-Cuyun Decoction on autoimmunity recurrent spontaneous abortion in recurrent spontaneous abortion.@*Methods@#To include eighty patients with autoimmunity recurrent spontaneous abortion from January 2016 to January 2018 in our hospital. The patients were divided into treatment group (36 cases) and control group (44 cases). The control group was treated with aspirin, and the treatment group was treated with Jiawei-Cuyun Decoction. The two groups, who were in the menstrual cycle, both were treated for 5 days until menstruation ends. The course of treatment for pregnancy should be no more than 3 menstrual cycles, and after pregnancy, the treatment should continue until the end of 12 weeks of pregnancy. During three menstrual cycles, the pregnancy serum anticardiolipin (aCL), anti-β2-1 glycoprotein (aβ2GP1) IgG and IgM were detected, and the adverse of drugs and pregnancy outcomes were recorded.@*Results@#For the third menstrual cycle, the overcast rates of serum aCL IgG [94.4% (34/36) vs. 68.2% (30/44); χ2=5.501, P=0.019], IgM [94.4% (34/36) vs. 77.3% (34/44); χ2=4.579, P=0.032], aβ2GP1 IgG [94.4% (34/36) vs. 75.0% (33/44); χ2=4.165, P=0.041], IgM [97.2% (35/36) vs. 79.5% (35/44); χ2=4.156, P=0.042] in the treatment group were significantly higher than those in the control group. After the treatment, the incidence of adverse reactions of the treatment group was 5.6% (2/36), and the control group was 31.8% (14/44), which showed that there was statistically significant difference between two groups (χ2=8.535, P=0.004). Pregnancy success rate of treatment group was 80.6% (29/36), and the control group was 56.8% (25/44), which showed that there was statistically significant difference between two groups (χ2=4.061, P=0.044).@*Conclusions@#Jiawei-Cuyun Decoction can effectively reduce the aCL, aβ2GP1 is IgG and IgM positive expression, reduce adverse drug reactions and improve the successful rate of pregnancy.
ABSTRACT
Objective:To investigate the specific effects of combined use of dinoprostone and phloroglucinol in painless delivery in full-term pregnant patients.Methods:100 primiparas admitted from Oct. 2016 to Oct. 2018 in our hospital were enrolled in this study. The 100 primiparas all met the following conditions: full-term pregnancy induced labor, singletons, no local complications, no maternity contraindications, no prostaglandins contraindications, no anesthesia contraindications and bishop scores of cervical were six points or less. By using the random number table method, they were divided into observation group and control group in the two groups, 50 cases in each group. Patients in the control group were induced labor by intravenous oxytocin infusion, and labor analgesia was performed under anesthesia when the opening of uterine orifice was 3 cm. In the observation group, labor induction mode was changed on the basis of the control group. Dinoprostone was used to induce labor at the posterior vaginal vault of the patient, and intravenous infusion of phloroglucinol was performed when the opening of uterine orifice was 3 cm and labor analgesia was performed under anesthesia. The cervical maturation rate, labor induction rate, specific labor process, pain degree and pregnancy outcome were compared between the two groups.Results:The effective rate of cervical maturation in the observation group (94.00%) was significantly higher than that in the control group (76.00%) , and the difference was statistically significant ( P<0.05) . The comparison results of pain degree between the two groups showed that: 36 cases (72.00%) with grade I pain in the observation group, significantly higher than 24 cases (48.00%) of the control group, and 2 cases (4.00%) with grade III pain in the observation group, significantly lower than 8 cases (16.00%) in the control group, with statistically significant differences ( P<0.05) . There was no significant difference between the two groups in term of the number of patients with grade II pain patients ( P>0.05) . There were 46 cases (92.00%) of successful labor induction in the observation group and 38 cases (76.00%) in the control group. The success rate of labor induction in the observation group was significantly higher than that in the control group, with statistically significant difference ( P<0.05) . The incubation period, active period, first stage and total length of labor in the observation group were significantly shorter than those in the control group, with statistically significant differences ( P<0.05) . There was no significant difference in the length of the second and third stages of labor between the two groups ( P>0.05) . There was no significant difference in neonatal asphyxia rate, Apgar score and postpartum blood loss between the two groups ( P>0.05) . Conclusion:The application of dinoprostone in painless delivery can effectively shorten the length of labor, and has a good effect on pain relief and smooth delivery, which can further accelerate the labor process of patients, accelerate cervical maturation, soften the cervix of patients, reduce spasm, and improve the rate of labor induction by combining with phloroglucinol, with more accurate efficacy.
ABSTRACT
Objective:To observe the effect of Jiawei-Cuyun Decoction on autoimmunity recurrent spontaneous abortion in recurrent spontaneous abortion. Methods:To include eighty patients with autoimmunity recurrent spontaneous abortion from January 2016 to January 2018 in our hospital. The patients were divided into treatment group (36 cases) and control group (44 cases). The control group was treated with aspirin, and the treatment group was treated with Jiawei-Cuyun Decoction. The two groups, who were in the menstrual cycle, both were treated for 5 days until menstruation ends. The course of treatment for pregnancy should be no more than 3 menstrual cycles, and after pregnancy, the treatment should continue until the end of 12 weeks of pregnancy. During three menstrual cycles, the pregnancy serum anticardiolipin (aCL), anti-β2-1 glycoprotein (aβ2GP1) IgG and IgM were detected, and the adverse of drugs and pregnancy outcomes were recorded. Results:For the third menstrual cycle, the overcast rates of serum aCL IgG [94.4% (34/36) vs. 68.2% (30/44); χ2=5.501, P=0.019], IgM [94.4% (34/36) vs. 77.3% (34/44); χ2=4.579, P=0.032], aβ2GP1 IgG [94.4% (34/36) vs. 75.0% (33/44); χ2=4.165, P=0.041], IgM [97.2% (35/36) vs. 79.5% (35/44); χ2=4.156, P=0.042] in the treatment group were significantly higher than those in the control group. After the treatment, the incidence of adverse reactions of the treatment group was 5.6% (2/36), and the control group was 31.8% (14/44), which showed that there was statistically significant difference between two groups ( χ2=8.535, P=0.004). Pregnancy success rate of treatment group was 80.6% (29/36), and the control group was 56.8% (25/44), which showed that there was statistically significant difference between two groups ( χ2=4.061, P=0.044). Conclusions:Jiawei-Cuyun Decoction can effectively reduce the aCL, aβ2GP1 is IgG and IgM positive expression, reduce adverse drug reactions and improve the successful rate of pregnancy.